Extracellular mitochondria drive CD8 T cell dysfunction in trauma by upregulating CD39

Abstract

The increased mortality and morbidity seen in critically injured patients appears associated with systemic inflammatory response syndrome (SIRS) and immune dysfunction, which ultimately predisposes to infection. Mitochondria released by injury could generate danger molecules, for example, ATP, which in turn would be rapidly scavenged by ectonucleotidases, expressed on regulatory immune cells.

Document Details

Document Type
Pub Defense Publication
Publication Date
May 25, 2022
Source ID
10.1136/thoraxjnl-2021-218047

Entities

People

  • Carl J. Hauser
  • Carola Ledderose
  • David Melton
  • Eva Csizmadia
  • Ghee Rye Lee
  • Guanqing Chen
  • James Harbison
  • Leo E Otterbein
  • Maria Serena Longhi
  • Quanzhi Zhang
  • Shilpa Tiwari-heckler
  • Simon Christopher Robson
  • Wolfgang Junger

Organizations

  • German Research Foundation
  • Istituto Superiore di Sanità
  • United States Department of Defense

Tags

Fields of Study

  • Medicine

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Immunology and Pathology
  • Thin Film Deposition Science.