Bio-chemical Assay Locking to Thwart Bio-IP Theft

Abstract

It is expected that as digital microfluidic biochips (DMFBs) mature, the hardware design flow will begin to resemble the current practice in the semiconductor industry: design teams send chip layouts to third-party foundries for fabrication. These foundries are untrusted and threaten to steal valuable intellectual property (IP). In a DMFB, the IP consists of not only hardware layouts but also of the biochemical assays (bioassays) that are intended to be executed on-chip. DMFB designers therefore must defend these protocols against theft. We propose to “lock” biochemical assays by inserting dummy mix-split operations. We experimentally evaluate the proposed locking mechanism, and show how a high level of protection can be achieved even on bioassays with low complexity. We also demonstrate a new class of attacks that exploit the side-channel information to launch sophisticated attacks on the locked bioassay.

Document Details

Document Type
Pub Defense Publication
Publication Date
Nov 22, 2019
Source ID
10.1145/3365579

Entities

People

  • Jack Tang
  • Krishnendu Chakrabarty
  • Mohamed Ibrahim
  • Ramesh Karri
  • Sudip Poddar
  • Sukanta Bhattacharjee

Organizations

  • Army Research Office
  • Duke University
  • Intel Corporation
  • National Science Foundation
  • New York University

Tags

Fields of Study

  • Computer science

Readers

  • Cybersecurity.
  • Integrated Circuit Design and Technology.
  • Molecular and Cellular Biology

Technology Areas

  • Microelectronics