Intestinal FFA3 mediates obesogenic effects in mice on a Western diet
Abstract
Here, we generated a novel intestine-specific knockout mouse model for FFA3 (Vil-FFA3) and performed a comprehensive metabolic characterization of mice in response to an obesogenic challenge. We found that Vil-FFA3 mice fed with a Western diet were largely protected from obesity, exhibiting significantly lower levels of fat mass, lower intestinal inflammation, and altered expression of intestinal incretin hormones. Results support an important role of intestinal FFA3 in contributing to metabolism and in the development of diet-induced obesity.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 01, 2022
- Source ID
- 10.1152/ajpendo.00016.2022
Entities
People
- Barton Wicksteed
- Brian T Layden
- Chioma Nnyamah
- Hariom L. Yadav
- Joseph L. Zapater
- Kai Xu
- Kristen Lednovich
- Medha Priyadarshini
- Shalini Jain
- Sidharth P Mishra
- Sophie Gough
Organizations
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Institute on Aging
- United States Department of Defense
- United States Department of Veterans Affairs
- University of Illinois at Chicago
- University of Illinois system
- University of South Florida