Severe acute pancreatitis exhibits distinct cytokine signatures and trajectories in humans: a prospective observational study
Abstract
In this study, we showed that the proinflammatory cytokine response in SAP is an early event, with subsequent downregulation of proinflammatory cytokines beginning at day 1 of symptom onset. Our findings underscore the importance of enrolling subjects very early in the disease course when conducting studies to investigate early immune events of SAP; this current study also serves as an important reference for the design of future biomarker studies and therapeutic trials in SAP.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Nov 01, 2022
- Source ID
- 10.1152/ajpgi.00100.2022
Entities
People
- Adam Lacy-Hulbert
- Anna Phillips
- Cate Speake
- David C Whitcomb
- Georgios I Papachristou
- Kim Stello
- Pedram Paragomi
- Peter J. Lee
- Phil Hart
- Phil J. Greer
Organizations
- National Institute of Diabetes and Digestive and Kidney Diseases
- Ohio State University
- United States Department of Defense
- United States Department of Veterans Affairs
- University of Pittsburgh
- University of Pittsburgh School of Medicine
- Virginia Mason Medical Center