Contributions of bile acids to gastrointestinal physiology as receptor agonists and modifiers of ion channels
Abstract
Bile acids (BAs) are known to be important regulators of intestinal motility and epithelial fluid and electrolyte transport. Over the past two decades, significant advances in identifying and characterizing the receptors, transporters, and ion channels targeted by BAs have led to exciting new insights into the molecular mechanisms involved in these processes. Our appreciation of BAs, their receptors, and BA-modulated ion channels as potential targets for the development of new approaches to treat intestinal motility and transport disorders is increasing. In the current review, we aim to summarize recent advances in our knowledge of the different BA receptors and BA-modulated ion channels present in the gastrointestinal system. We discuss how they regulate motility and epithelial transport, their roles in pathogenesis, and their therapeutic potential in a range of gastrointestinal diseases.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 01, 2022
- Source ID
- 10.1152/ajpgi.00125.2021
Entities
People
- Alexandr V. Ilyaskin
- Andreacarola Urso
- Christoph Korbmacher
- Daniel P Poole
- Nigel W Bunnett
- Simona E. Carbone
- Stephen J. Keely
Organizations
- Australian Research Council
- Columbia University
- Department of Health and Social Care
- Friedrich-Alexander-Universität Erlangen-Nürnberg
- Monash University
- National Institute of Dental and Craniofacial Research
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Institute of Neurological Disorders and Stroke
- New York University
- Royal College of Surgeons in Ireland
- Science Foundation Ireland
- United States Department of Defense