Severe acute pancreatitis: capillary permeability model linking systemic inflammation to multiorgan failure
Abstract
Acute pancreatitis is a sudden inflammatory response to pancreatic injury that may spread to systemic inflammation, multiorgan failure, and death in some patients. With the use of the predictions of a new mechanistic model, we compared patients with severe acute pancreatitis with or without multiorgan failure. All biomarkers of capillary leak and clinical features of multiorgan failure were accurately predicted. This provides a new paradigm for understanding and developing new treatments for patients with severe acute pancreatitis.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Nov 01, 2020
- Source ID
- 10.1152/ajpgi.00285.2020
Entities
People
- Anette S. Wilson
- Cameron Breze
- David C Whitcomb
- Georgios I Papachristou
- Nicole L. Komara
- Pedram Paragomi
- Phil J. Greer
Organizations
- United States Department of Defense
- University of Pittsburgh