Animal models of gastrointestinal and liver diseases. Animal models of acute and chronic pancreatitis
Abstract
Animal models of pancreatitis are useful for elucidating the pathogenesis of pancreatitis and developing and testing novel interventions. In this review, we aim to summarize the most commonly used animal models, overview their pathophysiology, and discuss their strengths and limitations. We will also briefly describe common animal study procedures and refer readers to more detailed protocols in the literature. Although animal models include pigs, dogs, opossums, and other animals, we will mainly focus on rodent models because of their popularity. Autoimmune pancreatitis and genetically engineered animal models will be reviewed elsewhere.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 01, 2016
- Source ID
- 10.1152/ajpgi.00372.2015
Entities
People
- Baoan Ji
- Fan Wang
- Xianbao Zhan
- Yan Bi
Organizations
- Congressionally Directed Medical Research Programs
- Mayo Clinic
- National Institutes of Health