An opioid receptor-independent mechanism underlies motility dysfunction and visceral hyperalgesia in opioid-induced bowel dysfunction
Abstract
Our preclinical study shows that fecal retention is a pathogenic factor in opioid-induced bowel dysfunction, as prevention of fecal retention with liquid diet improved motility and attenuated visceral hyperalgesia in morphine-treated animals by blocking expression of cyclooxygenase-2 and nerve growth factor in the colon.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 01, 2021
- Source ID
- 10.1152/ajpgi.00400.2020
Entities
People
- Daniel W. Shi
- Li-yen M. Huang
- Shrilakshmi Hegde
- Xuan-Zheng Shi
- Yanbo Tang
- You-min Lin
- Yu Fu
Organizations
- Guangxi University of Science and Technology
- National Institute of Diabetes and Digestive and Kidney Diseases
- Texas A&M University
- United States Department of Defense
- University of Texas Medical Branch