Low-dose morphine reduces tolerance to central hypovolemia in healthy adults without affecting muscle sympathetic outflow
Abstract
In this randomized, crossover, placebo-controlled trial, we found that tolerance to simulated hemorrhage was lower after low-dose morphine administration. Such reductions in hemorrhagic tolerance were observed without differences in MSNA burst frequency responses between morphine and placebo trials. These data, the first to be obtained in conscious humans, demonstrate that low-dose morphine reduces hemorrhagic tolerance. Thus, morphine is not an ideal analgesic for a hemorrhaging individual in the prehospital setting.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 01, 2022
- Source ID
- 10.1152/ajpheart.00091.2022
Entities
People
- Bonnie D. Orth
- Carmen Hinojosa-Laborde
- Craig G Crandall
- Elias Johnson
- Frank A. Cimino 3rd
- Joseph C Watso
- Joseph M Hendrix
- Josh Foster
- Luke N Belval
- Mu Huang
Organizations
- American Physiological Society
- Institute for Exercise and Environmental Medicine
- National Heart, Lung, and Blood Institute
- United States Army Institute of Surgical Research
- United States Department of Defense
- University of Texas at Austin