Low-dose morphine reduces pain perception and blood pressure, but not muscle sympathetic outflow, responses during the cold pressor test
Abstract
In this randomized, crossover, placebo-controlled trial, we found that low-dose morphine administration reduced pain perception and blood pressure responses during the cold pressor test via attenuated increases in heart rate and cardiac output. We also determined that muscle sympathetic outflow responses during the cold pressor test seem to be unaffected by low-dose morphine administration. Finally, our exploratory analysis suggests that biological sex does not influence morphine-induced antinociception in healthy adults.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 01, 2022
- Source ID
- 10.1152/ajpheart.00092.2022
Entities
People
- Bonnie D. Orth
- Carmen Hinojosa-Laborde
- Craig G Crandall
- Elias Johnson
- Frank A. Cimino 3rd
- Joseph C Watso
- Joseph M Hendrix
- Josh Foster
- Luke N Belval
- Mu Huang
Organizations
- American Physiological Society
- Institute for Exercise and Environmental Medicine
- National Heart, Lung, and Blood Institute
- United States Army Institute of Surgical Research
- United States Department of Defense
- University of Texas at Austin