Analysis of Drosophila cardiac hypertrophy by microcomputerized tomography for genetic dissection of heart growth mechanisms
Abstract
Genetic analysis of Drosophila cardiac hypertrophy holds immense potential for the discovery of new therapeutic targets to prevent and treat heart failure. This potential has been hindered by a lack of rapid and effective methods for analyzing heart size in flies. Here, we demonstrate that analysis of the Drosophila heart with microcomputerized tomography yields accurate and highly reproducible heart size measurements that can be used to analyze heart growth and cardiac hypertrophy in Drosophila.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 01, 2022
- Source ID
- 10.1152/ajpheart.00387.2021
Entities
People
- Benjamin A. Tripoli
- Courtney E. Petersen
- Jeremy T Smyth
- Todd A Schoborg
Organizations
- F. Edward Hébert School of Medicine
- National Heart, Lung, and Blood Institute
- National Institute of General Medical Sciences
- National Institute of Neurological Disorders and Stroke
- Office of the Director
- Uniformed Services University of the Health Sciences
- University of Wyoming