Preserved β-adrenergic-mediated vasodilation in skeletal muscle of young adults with obesity despite shifts in cyclooxygenase and nitric oxide synthase
Abstract
We examined β-adrenergic receptor-mediated vasodilation in skeletal muscle of normal weight and humans with obesity. Results show that despite shifts in the contribution of cyclooxygenase and nitric oxide synthase, β-adrenergic-mediated vasodilation is relatively preserved in young, otherwise healthy adults with obesity. These data highlight the presence of subclinical changes in microvascular control mechanisms early in the obesity process and suggest duration of obesity and/or the addition of primary aging may be necessary for overt dysfunction.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 01, 2022
- Source ID
- 10.1152/ajpheart.00449.2021
Entities
People
- Benjamin J. Walker
- Garrett L. Peltonen
- Jacqueline K. Limberg
- Jeremy Mikhail Kellawan
- John W. Harrell
- Joshua J. Sebranek
- Katrina J. Carter
- Marlowe W. Eldridge
- Rebecca E. Johansson
- William G. Schrage
Organizations
- 711th Human Performance Wing
- National Center for Advancing Translational Sciences
- National Heart, Lung, and Blood Institute
- University of Missouri
- University of Oklahoma
- University of Wisconsin–Madison
- Western New Mexico University