Hypertension promotes microbial translocation and dysbiotic shifts in the fecal microbiome of nonhuman primates
Abstract
Hypertension specifically had detrimental effects on microbial translocation when age and metabolic syndrome criteria were evaluated as drivers of cardiovascular disease in a relevant nonhuman primate model. Intestinal barrier function exponentially decayed over time with chronic hypertension, and microbial translocation was confirmed by detection of more microbial genes in regional draining lymph nodes. Chronic hypertension resulted in fecal microbial dysbiosis and elevations of the biomarker NT-proBNP. This study provides insights on the barrier dysfunction, dysbiosis, and hypertension in controlled studies of nonhuman primates. Our study includes a longitudinal component comparing naturally occurring hypertensive to normotensive primates to confirm microbial translocation and dysbiotic microbiome development. Hypertension is an underappreciated driver of subclinical endotoxemia that can drive chronic inflammatory diseases
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 01, 2022
- Source ID
- 10.1152/ajpheart.00530.2021
Entities
People
- Alistaire Ruggiero
- Greg O. Dugan
- Hao Guo
- J M Cline
- Jordyn M. Whitfield
- Kylie Kavanagh
- Masha R. Block
- Ravichandra Vemuri
Organizations
- National Heart, Lung, and Blood Institute
- National Institute of Allergy and Infectious Diseases
- National Institutes of Health
- Office of the Director
- United States Department of Defense
- University of North Carolina at Chapel Hill
- University of Tasmania
- Wake Forest School of Medicine