Elevated postischemic tissue injury and leukocyte-endothelial adhesive interactions in mice with global deficiency in caveolin-2: role of PAI-1
Abstract
The role of caveolin-2 in regulating ischemia/reperfusion (I/R) tissue injury and the mechanisms underlying its effects are unknown. This study uses caveolin-2-deficient mouse and small intestinal I/R injury models to examine the role of caveolin-2 in the leukocyte-dependent reperfusion injury. We demonstrate for the first time that caveolin-2 plays a protective role from the I/R-induced leukocyte-dependent reperfusion injury by reducing PAI-1 protein levels in intestinal tissue and leukocyte-endothelial adhesive interactions in postcapillary venules.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 01, 2021
- Source ID
- 10.1152/ajpheart.00682.2020
Entities
People
- Derek Wang
- Grzegorz Sowa
- Meifang Wang
- Ronald J. Korthuis
- William P. Fay
- Yajun Liu
Organizations
- National Heart, Lung, and Blood Institute
- National Institute on Alcohol Abuse and Alcoholism
- United States Department of Defense
- University of Missouri