Chronic perinatal hypoxia delays cardiac maturation in a mouse model for cyanotic congenital heart disease
Abstract
We utilized a new mouse model of chronic perinatal hypoxia to simulate the hypoxic myocardial conditions present in cyanotic congenital heart disease. Hypoxia caused numerous abnormalities in cardiomyocyte gene expression, the electrophysiologic substrate of the heart, and contractile function. Taken together, alterations observed in the neonatal period suggest delayed cardiac development immediately following hypoxia.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 01, 2021
- Source ID
- 10.1152/ajpheart.00870.2020
Entities
People
- Colm Mulvany
- Devon Guerrelli
- Jennifer Romanowicz
- Linda Leatherbury
- Luther Swift
- Manelle Ramadan
- Marissa Reilly
- Nikki Gillum Posnack
- Nimisha Vasandani
- Nobuyuki Ishibashi
- Zaenab Dhari
Organizations
- Children's National Hospital
- George Washington University
- National Institutes of Health
- Office of the Secretary of Defense