Gamma secretase activating protein promotes end-organ dysfunction after bacterial pneumonia
Abstract
Pneumonia is a common cause of end-organ dysfunction, both during and in the aftermath of infection. In particular, pneumonia is a common cause of lung injury, increased risk of myocardial infarction, and neurocognitive dysfunction, although the mechanisms responsible for such increased risk are unknown. Here, we reveal that gamma-secretase activating protein, which contributes to the amyloidogenic pathway, is important for end-organ dysfunction following infection.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Aug 01, 2023
- Source ID
- 10.1152/ajplung.00018.2023
Entities
People
- Amy R. Nelson
- Aron M Geurts
- Chun Zhou
- Dara W. Frank
- Dhananjay Tambe
- Domenico Spadafora
- James M. Downey
- Jessica Bell
- Ji Young Lee
- Jonathon P. Audia
- Linn Ayers
- M.S. Gwin
- Michael V. Cohen
- Mike T. Lin
- Mikhail F Alexeyev
- Robert A. Barrington
- Ron Balczon
- Sarah Voth
- Troy Stevens
- Viktoriya V. Pastukh
- Xi-ming Yang
Organizations
- American Heart Association
- Edward Via College of Osteopathic Medicine
- Medical College of Wisconsin
- National Heart, Lung, and Blood Institute
- National Institute on Aging
- Office of the Director
- United States Department of Defense
- University of South Alabama