A pro-con debate: current controversies in PAH pathogenesis at the American Thoracic Society International Conference in 2017
Abstract
The following review summarizes the pro-con debate about current controversies regarding the pathogenesis of pulmonary arterial hypertension (PAH) that took place at the American Thoracic Society Conference in May 2017. Leaders in the field of PAH research discussed the importance of the immune system, the role of hemodynamic stress and endothelial apoptosis, as well as bone morphogenetic protein receptor-2 signaling in PAH pathogenesis. Whereas this summary does not intend to resolve obvious conflicts in opinion, we hope that the presented arguments entice further discussions and draw a new generation of enthusiastic researchers into this vibrant field of science to bridge existing gaps for a better understanding and therapy of this fatal disease.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 01, 2018
- Source ID
- 10.1152/ajplung.00150.2018
Entities
People
- Andrea Olschewski
- Duncan Stewart
- Edda Spiekerkoetter
- Kohtaro Abe
- Mark R. Nicolls
- Marlene Rabinovitch
- Nicholas W. Morrell
- Stephen L. Archer
- Stephen Y Chan
- Wolfgang M Kuebler
Organizations
- American Heart Association
- Austrian Agency for International Cooperation in Education and Research
- Austrian National Bank
- Austrian Science Fund
- British Heart Foundation
- German Center for Lung Research
- German Centre for Cardiovascular Research
- German Research Foundation
- Heart and Stroke Foundation of Canada
- Institute of Physiology
- Japan Society for the Promotion of Science
- Johannes Kepler University Linz
- Kyushu University
- Medical University of Graz
- National Heart, Lung, and Blood Institute
- National Institutes of Health
- Ottawa Hospital Research Institute
- Pulmonary Hypertension Association
- Queen's University
- Stanford University
- United States Department of Defense
- University of Cambridge
- University of Pittsburgh School of Medicine
- University of Toronto