Emerging insights in sarcoidosis: moving forward through reverse translational research
Abstract
Sarcoidosis is a chronic granulomatous disease of unknown etiology that primarily affects the lungs. The development of stage IV or fibrotic lung disease accounts for a significant proportion of the morbidity and mortality attributable to sarcoidosis. Further investigation into the active mechanisms of disease pathogenesis and fibrogenesis might illuminate fundamental mediators of injury and repair while providing new opportunities for clinical intervention. However, progress in sarcoidosis research has been hampered by the heterogeneity of clinical phenotypes and the lack of a consensus modeling system. Recently, reverse translational research, wherein observations made at the patient level catalyze hypothesis-driven research at the laboratory bench, has generated new discoveries regarding the immunopathogenic mechanisms of pulmonary granuloma formation, fibrogenesis, and disease model development. The purpose of this review is to highlight the promise and possibility of these novel investigative efforts.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 01, 2022
- Source ID
- 10.1152/ajplung.00266.2021
Entities
People
- Angela Liu
- Changwan Ryu
- Charles S Dela Cruz
- Erica L Herzog
- Lokesh Sharma
- Xiting Yan
Organizations
- American College of Chest Physicians
- American Lung Association
- Boehringer Ingelheim (United States)
- Elias Foundation
- Francis Family Foundation
- National Heart, Lung, and Blood Institute
- United States Department of Defense
- United States Department of Veterans Affairs
- Yale University