Metabolomic profiling demonstrates evidence for kidney and urine metabolic dysregulation in a piglet model of cardiac surgery-induced acute kidney injury
Abstract
This project explored the metabolic underpinnings of postoperative acute kidney injury (AKI) following pediatric cardiac surgery in a translationally relevant large animal model of cardiopulmonary bypass with deep hypothermic circulatory arrest. Here, we present novel evidence for dysregulated tryptophan catabolism and purine catabolism in kidney tissue and increased urinary glycolysis intermediates in animals who developed histological AKI. These pathways represent potential diagnostic and therapeutic targets for postoperative AKI in this high-risk population.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 01, 2022
- Source ID
- 10.1152/ajprenal.00039.2022
Entities
People
- Amy Treece
- Benjamin S Frank
- Danielle E. Soranno
- Eiman Ali
- James Jaggers
- Jelena Klawitter
- Jesse Davidson
- John Iguidbashian
- Justin Robison
- Ludmila Khailova
- Richard J Ing
- Scott Lawson
- Suzanne Osorio Lujan
Organizations
- American Heart Association
- Heart Institute
- National Heart, Lung, and Blood Institute
- United States Department of Defense
- University of Colorado
- Washington University in St. Louis