Secondary denervation is a chronic pathophysiologic sequela of volumetric muscle loss
Abstract
This work advances our understanding of the pathophysiologic complexity of volumetric muscle loss injury. Specifically, we identified secondary denervation in the muscle remaining after volumetric muscle loss injuries as a novel aspect of the injury sequela. Denervation increased chronically, in parallel with the appearance of irregular morphological characteristics and destabilization of the neuromuscular junction, which is expected to further confound chronic functional impairments.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 01, 2021
- Source ID
- 10.1152/japplphysiol.00049.2021
Entities
People
- Benjamin T. Corona
- Daniel B. Hoffman
- Jacob R Sorensen
- Sarah M Greising
Organizations
- United States Department of Defense
- University of Minnesota
- Wake Forest University