Ovariectomy aggravates the pathophysiological response to exertional heat stroke in mice
Abstract
Females outperform males in a mouse model of exertional heat stroke (EHS). Here, we show for the first time the impact of ovariectomy (OVX) on EHS pathophysiology. OVX resulted in a shorter exercise capacity in the heat, greater intestinal damage, and lower heat shock response following EHS.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 01, 2023
- Source ID
- 10.1152/japplphysiol.00092.2023
Entities
People
- Christian K. Garcia
- Daniel R Machin
- Isela Valera
- Liliana I. Rentería
- Lisa R. Leon
- Orlando Laitano
- Xiangyu Zheng
Organizations
- Florida State University
- National Center for Complementary and Integrative Health
- United States Department of Defense
- University of Florida