Effects of extremity trauma on physiological responses to hemorrhage in conscious rats
Abstract
In both civilian and military settings, severe hemorrhage rarely occurs in the absence of tissue trauma, yet many animal models for the study of hemorrhage do not include significant tissue trauma. This study using conscious unrestrained rats clearly demonstrates that extremity trauma worsens the probability of survival after a severe hemorrhage. Although no single cardiorespiratory factor accounted for the increased mortality, multiple modest time-related cardiorespiratory responses to the trauma were observed suggesting that their combined dysfunction may have contributed to the reduced survival.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 01, 2023
- Source ID
- 10.1152/japplphysiol.00191.2022
Entities
People
- Carmen Hinojosa-Laborde
- Harold G. Klemcke
- Kathy L. Ryan
- Lusha Xiang
- Mariam L. Calderon
Organizations
- United States Army Institute of Surgical Research