Administration of particulate oxygen generators improves skeletal muscle contractile function after ischemia-reperfusion injury in the rat hindlimb
Abstract
Skeletal muscle contraction was evaluated in the same animals at multiple time points up to 4 wk after injury, following administration of particulate oxygen generators (POGs) in a clinically relevant rat hindlimb model of tourniquet-induced ischemia. The observed POG-mediated improvement of muscle function over time confirms and extends previous studies to further document the potential clinical applications of POGs. Of particular significance in austere environments, this technology can be applied in the absence of an intact circulation.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 01, 2022
- Source ID
- 10.1152/japplphysiol.00259.2021
Entities
People
- Aishwarya Hombal
- George J. Christ
- J. David Remer
- Joseph C Wenke
- Kelsey E. Hannifin
- Sarah E. Dyer
- Thomas J. Walters
Organizations
- United States Army Institute of Surgical Research
- University of Virginia