Protective ventilation in a pig model of acute lung injury: timing is as important as pressure
Abstract
In a large animal model of ARDS, recruitment/derecruitment caused greater VILI than overdistension, whereas both mechanisms together caused severe lung damage. These findings suggest that eliminating cyclic recruitment and derecruitment during mechanical ventilation should be a preeminent management goal for the patient with ARDS. The airway pressure release ventilation (APRV) mode of mechanical ventilation can achieve this if delivered with an expiratory duration (TLow) that is brief enough to prevent derecruitment at end expiration.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Nov 01, 2022
- Source ID
- 10.1152/japplphysiol.00312.2022
Entities
People
- Auyon J. Ghosh
- Benjamin Robedee
- Donald P. Gaver
- Gary F Nieman
- Guirong Wang
- Harry Ramcharran
- James Vossler
- Jason H T Bates
- Joshua Satalin
- Louis A. Gatto
- Michaela Kollisch-Singule
- Nader M. Habashi
- Nirav Daphtary
- Penny L. Andrews
- Sarah Blair
Organizations
- Congressionally Directed Medical Research Programs
- National Heart, Lung, and Blood Institute
- R Adams Cowley Shock Trauma Center
- State University of New York Upstate Medical University
- Tulane University of Louisiana
- University of Vermont