A model of anemic tissue perfusion after blood transfusion shows critical role of endothelial response to shear stress stimuli
Abstract
Transfusion of 1 or 2 units of blood accounts for about 3/4 of the world blood consumption of 119 million units per year, whereas a current world demand deficit is on the order of 100 million units. Therefore, factors supporting the practice of transfusing 1 unit instead of 2 are of interest, given their potential to expand the number of interventions without increasing blood availability. Our mathematical model provides a physiological support for this practice.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Dec 01, 2021
- Source ID
- 10.1152/japplphysiol.00524.2021
Entities
People
- Amy G. Tsai
- Daniel M. Tartakovsky
- Marcos Intaglietta
- Weiyu Li
Organizations
- Air Force Office of Scientific Research
- Stanford University
- University of California, San Diego