Kidney injury risk during prolonged exposure to current and projected wet bulb temperatures occurring during extreme heat events in healthy young men
Abstract
We have demonstrated that kidney injury risk is increased when men are exposed over an eight hour period to a wet bulb temperature of 31{degree sign}C and exacerbated at a wet bulb temperature of 34{degree sign}C. Importantly, these heat stress conditions parallel those that are encountered during current (31{degree sign}C) and future (34{degree sign}C) extreme heat events. The kidney injury biomarker analyses indicate both the proximal and distal tubules as the locations of potential renal injury, and that the injury is likely due to oxidative stress and inflammation.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 01, 2022
- Source ID
- 10.1152/japplphysiol.00601.2021
Entities
People
- Blair D Johnson
- Christopher L. Chapman
- David Basile
- David Hostler
- Hayden W Hess
- Jacob C. Monroe
- Jocelyn J. Stooks
- Riana R Pryor
- Tyler B. Baker
- Zachary J Schlader
Organizations
- Indiana Clinical and Translational Sciences Institute
- Indiana University
- National Institute for Occupational Safety and Health
- National Institute of Diabetes and Digestive and Kidney Diseases
- Naval Sea Systems Command
- University at Buffalo
- University of Oregon