Neuromuscular electrical stimulation resistance training enhances oxygen uptake and ventilatory efficiency independent of mitochondrial complexes after spinal cord injury: a randomized clinical trial
Abstract
Leg oxygen uptake (V̇o2) peak, ventilatory efficiency (V̇E/V̇co2 ratio), and substrate utilization were measured during functional electrical stimulation cycling FES-LEC testing following 12–16 wk of either electrically evoked resistance training or passive movement training; indirect calorimetry and mitochondrial complex levels in muscle biopsies were also determined. FES-LEC increased thigh muscle area and leg V̇o2 peak increased but decreased V̇E/V̇co2 ratio; there were no changes in mitochondrial complex levels. Leg V̇o2 peak was associated with hypertrophy of the paralyzed muscles and mitochondrial respiration of complex I following training.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 01, 2021
- Source ID
- 10.1152/japplphysiol.01029.2020
Entities
People
- Ashraf S Gorgey
- Christopher Cardozo
- Edward J. Lesnefsky
- Jeannie Rivers
- Qun Chen
- Raymond E. Lai
- Refka E. Khalil
Organizations
- Congressionally Directed Medical Research Programs
- Hunter Holmes McGuire Veterans Administration Medical Center
- Icahn School of Medicine at Mount Sinai
- James J. Peters VA Medical Center
- Virginia Commonwealth University