Neuroinflammation with increased glymphatic flow in a murine model of decompression sickness
Abstract
A murine model of central nervous system (CNS) decompression sickness demonstrates that high gas pressure activates astrocytes and microglia triggering inflammatory microparticle (MP) production. Thrombospondin-expressing MPs are released from the CNS via enhanced glymphatic flow to the systemic circulation where they activate neutrophils. Secondary production of neutrophil-derived MPs causes further cell activation and neutrophil adherence to the brain microvasculature establishing a feed-forward neuroinflammatory cycle.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 01, 2023
- Source ID
- 10.1152/jn.00005.2023
Entities
People
- Abid R. Bhat
- Awadhesh K. Arya
- Deepa Ruhela
- Guanda Qiao
- Shiyu Tang
- Stephen R. Thom
- Su Xu
- Veena M. Bhopale
- Xin Li
Organizations
- National Institute of Neurological Disorders and Stroke
- Office of Naval Research
- University of Maryland School of Medicine