Effects of Ih and TASK-like shunting current on dendritic impedance in layer 5 pyramidal-tract neurons
Abstract
We simulated chirp current stimulation in the apical dendrites of 5 biophysically detailed multicompartment models of neocortical pyramidal tract neurons and found that a combination of HCN channels and TASK-like channels produced the best fit to experimental measurements of dendritic impedance. We then explored how HCN and TASK-like channels can shape the dendritic impedance as well as the voltage response to synaptic currents.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 01, 2021
- Source ID
- 10.1152/jn.00015.2021
Entities
People
- Craig Kelley
- Michele Migliore
- Nicholas T. Carnevale
- Salvador Dura-bernal
- Samuel A. Neymotin
- Srdjan D. Antic
- William W. Lytton
Organizations
- Army Research Office
- Grossman School of Medicine
- Kings County Hospital Center
- Nathan Kline Institute for Psychiatric Research
- National Institute on Deafness and Other Communication Disorders
- National Institutes of Health
- National Science Foundation
- New York State Department of Health
- SUNY Downstate College of Medicine
- Yale University