Sensitivity of unilateral- versus bilateral-onset spike-wave discharges to ethosuximide and carbamazepine in the fluid percussion injury rat model of traumatic brain injury
Abstract
Unilateral-onset spike-wave discharges (SWDs) in rats have been used to model complex partial seizures in human posttraumatic epilepsy (PTE), compared to bilateral-onset SWDs thought to reflect human absence seizures. Here, we show that both unilateral- and bilateral-onset SWDs following traumatic brain injury are suppressed by the antiabsence drug ethosuximide and are unaffected by the antiseizure drug carbamazepine. We propose that unilateral-onset SWDs are not useful for studying mechanisms of, or treatments for, PTE.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 01, 2021
- Source ID
- 10.1152/jn.00098.2021
Entities
People
- Daniel S Barth
- David J. Poulsen
- F. Edward Dudek
- Jeremy A. Taylor
- Sean Tatum
- Zachariah Z. Smith
Organizations
- Citizens United for Research in Epilepsy
- Congressionally Directed Medical Research Programs
- University at Buffalo
- University of Colorado
- University of Utah