Compensatory saccades differ between those with vestibular hypofunction and multiple sclerosis pointing to unique roles for peripheral and central vestibular inputs
Abstract
Compensatory saccades (CSs) are recruited by individuals with unilateral vestibular deafferentation (UVD) to compensate for an impaired vestibulo-ocular reflex (VOR). The effectiveness of CS in multiple sclerosis (MS), a central vestibular impairment, is unknown. We show that in UVD and in MS, covert CSs compensate for reduced VOR gain and minimize gaze position error (GPE), yet in >50% of individuals with MS, overt CS worsened GPE, suggesting unique roles for peripheral and central vestibular inputs.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 01, 2022
- Source ID
- 10.1152/jn.00220.2022
Entities
People
- Andrew R. Wagner
- Brian J Loyd
- Colin R. Grove
- Leland E. Dibble
- Michael C Schubert
Organizations
- Foundation for Physical Therapy
- Johns Hopkins University
- National Multiple Sclerosis Society
- Ohio State University
- United States Department of Defense
- University of Montana
- University of Utah