The impact of targeted ablation of one row of outer hair cells and Deiters’ cells on cochlear amplification
Abstract
Normal cochlear physiology involves force production from three rows of outer hair cells to amplify and tune the traveling wave. Here, we used a genetic approach to target and ablate the third row of outer hair cells in the mouse cochlea and found it reduced cochlear amplification by 79%. This means that the loss of even a relatively small number of OHCs, when evenly distributed, causes a substantial reduction in cochlear amplification.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Nov 01, 2022
- Source ID
- 10.1152/jn.00501.2021
Entities
People
- Alan G Cheng
- Anping Xia
- Brian E Applegate
- John S Oghalai
- Patricia M. Quiñones
- Patrick J. Atkinson
- Tomokatsu Udagawa
Organizations
- Jikei University School of Medicine
- National Institute of Biomedical Imaging and Bioengineering
- National Institute on Deafness and Other Communication Disorders
- Naval Health Research Center
- Stanford University
- University of Southern California