Abnormal development of auditory responses in the inferior colliculus of a mouse model of Fragile X Syndrome
Abstract
Autism spectrum disorders (ASD) are commonly associated with sensory sensitivity issues, but the underlying mechanisms are unclear. This study presents novel evidence for neural correlates of auditory hypersensitivity in the developing inferior colliculus (IC) in the Fmr1 knockout (KO) mouse, a mouse model of Fragile X Syndrome (FXS), a leading genetic cause of ASD. Responses begin to show genotype differences between postnatal days 14 and 21, suggesting an early developmental treatment window.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 01, 2020
- Source ID
- 10.1152/jn.00706.2019
Entities
People
- Anna O. Nguyen
- Devin K. Binder
- Iryna M Ethell
- Khaleel A. Razak
Organizations
- United States Department of Defense
- University of California