Dynamic transcriptomic responses to divergent acute exercise stimuli in young adults
Abstract
We examined small and long transcriptomics in skeletal muscle and serum-derived extracellular vesicles before and after a single exposure to traditional combined exercise (TRAD) and high-intensity tactical training (HITT). Across 40 young adults, we found more consistent protein-coding gene responses to TRAD, whereas HITT elicited differential expression of microRNA enriched in brain regions. Follow-up analysis revealed relationships and temporal dynamics across transcript networks, highlighting potential avenues for research into mechanisms of exercise response and adaptation.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 01, 2023
- Source ID
- 10.1152/physiolgenomics.00144.2022
Entities
People
- Amber Sullivan
- Anna Bonfitto
- Bessie Meechoovet
- Brandon Peoples
- Christian J. Kelley
- Devin Drummer
- Elizabeth Hutchins
- Eric Alsop
- Inmaculada Aban
- Jeremy S. Mcadam
- Jerry Antone
- Joanna Palade
- Joshua S. Talboom
- Kaleen Lavin
- Kalyani Peri
- Kendall R Van Keuren-Jensen
- Manoel E. Lixandrão
- Marcas M Bamman
- Margaret B. Bell
- Matthew J. Huentelman
- Patrick Pirrotte
- Rebecca Reiman
- Regina S. Seay
- S. Craig Tuggle
- Samia M. O’bryan
- Timothy J. Broderick
- Zachary A. Graham
Organizations
- City of Hope National Medical Center
- Florida Institute for Human and Machine Cognition
- National Cancer Institute
- Office of Naval Research
- Translational Genomics Research Institute
- United States Department of Veterans Affairs
- University of Alabama at Birmingham