Buckysomes: New Nanocarriers for Anticancer Drugs
Abstract
Buckysomes, liposome-like vesicles comprised of dendritic C60 subunits that self-assemble into unilamellar vesicles, are unique nanovectors that have utility in drug delivery. We have prepared paclitaxel-embedded buckysomes (PEBs) and examined biodistriubition profiles with commercially available formulations of the drug. As compared to Abraxane, an albumin-bound formulation of paclitaxel, PEBs showed higher tissue accumulation in the liver and the kidney at 45 and 60 minutes and in the lungs at 30 minutes, making them suitable drug-delivery carriers for short-term therapy to the mentioned organs. These buckysomes can be further functionalized to specifically deliver paclitaxel to the tumor site.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 28, 2013
- Source ID
- 10.1155/2013/390425
Entities
People
- Delia Danila
- Eva Golunski
- Jodie Conyers
- Madonna Mcmanus
- Ranga Partha
- Tina Little
Organizations
- Biomatrica
- United States Department of Defense
- University of Texas Health Science Center at Houston