Circulating Cancer-Associated Macrophage-Like Cells Differentiate Malignant Breast Cancer and Benign Breast Conditions
Abstract
Background: Blood-based testing can be used as a noninvasive method to recover and analyze circulating tumor-derived cells for clinical use. Circulating cancer-associated macrophage-like cells (CAML) are specialized myeloid cells found in peripheral blood and associated with the presence of solid malignancies. We measured CAMLs prospectively in peripheral blood to ascertain their prevalence, specificity, and sensitivity in relation to breast disease status at clinical presentation.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 30, 2016
- Source ID
- 10.1158/1055-9965.epi-15-1221
Entities
People
- Cha-Mei Tang
- Daniel L Adams
- Diane K. Adams
- Jeffrey R. Marks
- Massimo Cristofanilli
- R. Katherine Alpaugh
- Saranya Chumsri
- Stuart S. Martin
Organizations
- Army Research Office
- National Cancer Institute
- Northwestern University
- Susan G. Komen for the Cure
- United States Department of Defense