Lifestyle and Reproductive Factors and Ovarian Cancer Risk by p53 and MAPK Expression

Abstract

Background: One model of ovarian cancer development model divides tumors into two types. Type I tumors are characterized by KRAS and BRAF mutations, which can activate mitogen-activated protein kinase (MAPK). Type II tumors are characterized by tubal precursor lesions with p53 mutations. We evaluated the association between lifestyle and reproductive factors and risk of ovarian cancer defined by p53 and MAPK expression.

Document Details

Document Type
Pub Defense Publication
Publication Date
Jan 01, 2018
Source ID
10.1158/1055-9965.epi-17-0609

Entities

People

  • Amy L. Shafrir
  • Elizabeth M Poole
  • Holly R Harris
  • Jonathan L Hecht
  • Kathryn L. Terry
  • Mamta Gupta
  • Megan S. Rice
  • Shelley S. Tworoger

Organizations

  • Fred Hutchinson Cancer Center
  • H. Lee Moffitt Cancer Center & Research Institute
  • Harvard Medical School
  • Harvard University
  • Massachusetts General Hospital
  • National Institutes of Health
  • United States Department of Defense

Tags

Readers

  • Breast cancer cell signaling and growth regulation.
  • Molecular and genetic basis of cancer.
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.