Collagen Alignment as a Predictor of Recurrence after Ductal Carcinoma In Situ
Abstract
Background: Collagen fibers surrounding breast ducts may influence breast cancer progression. Syndecan-1 interacts with constituents in the extracellular matrix, including collagen fibers, and may contribute to cancer cell migration. Thus, the orientation of collagen fibers surrounding ductal carcinoma in situ (DCIS) lesions and stromal syndecan-1 expression may predict recurrence.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 01, 2018
- Source ID
- 10.1158/1055-9965.epi-17-0720
Entities
People
- Amy Trentham-dietz
- Andreas Friedl
- Brian L. Sprague
- Jeremy S. Bredfeldt
- John M. Hampton
- Kevin Eliceiri
- Lisa Van Gemert
- Matthew W Conklin
- Nuntida Surachaicharn
- Patricia J. Keely
- Polly A. Newcomb
- Ronald E. Gangnon
- Yuming Liu
Organizations
- Congressionally Directed Medical Research Programs
- National Cancer Institute
- National Institutes of Health
- University of Vermont
- University of Wisconsin Hospital and Clinics
- University of Wisconsin–Madison