Epigenetically Silenced Candidate Tumor Suppressor Genes in Prostate Cancer: Identified by Modeling Methylation Stratification and Applied to Progression Prediction
Abstract
Recent studies have shown that epigenetic alterations, especially the hypermethylated promoters of tumor suppressor genes (TSGs), contribute to prostate cancer progression and metastasis. This article proposes a novel algorithm to identify epigenetically silenced TSGs (epi-TSGs) for prostate cancer.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 01, 2019
- Source ID
- 10.1158/1055-9965.epi-18-0491
Entities
People
- Erik K Flemington
- Hong-wen Deng
- Kun Zhang
- Wensheng Zhang
Organizations
- National Institutes of Health
- Tulane University of Louisiana
- United States Department of Defense