Intratumoral Sterol-27-Hydroxylase (CYP27A1) Expression in Relation to Cholesterol Synthesis and Vitamin D Signaling and Its Association with Lethal Prostate Cancer
Abstract
Higher intratumoral cholesterol synthesis is associated with a worse prognosis in prostate cancer. The vitamin D–regulated enzyme sterol-27-hydroxylase (CYP27A1) converts cholesterol to 27-hydroxycholesterol, potentially lowering intracellular cholesterol levels. We hypothesized that low CYP27A1 expression is associated with high cholesterol synthesis, low vitamin D signaling, and higher risk of lethal prostate cancer.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 01, 2019
- Source ID
- 10.1158/1055-9965.epi-18-1083
Entities
People
- Edward L. Giovannucci
- Emma H Allott
- Konrad H Stopsack
- Lorelei A. Mucci
- Nabeela A. Khan
- Philip W. Kantoff
- Travis Gerke
Organizations
- Brigham and Women's Hospital
- Dana Farber Harvard Cancer Center
- H. Lee Moffitt Cancer Center & Research Institute
- Harvard University
- Memorial Sloan Kettering Cancer Center
- National Institutes of Health
- Trinity College Dublin
- United States Department of Defense