FOXA1 Protein Expression in ER+ and ER− Breast Cancer in Relation to Parity and Breastfeeding in Black and White Women
Abstract
Forkhead box protein A1 (FOXA1) promotes luminal differentiation, and hypermethylation of the gene can be a mechanism of developing estrogen receptor–negative (ER−) breast cancer. We examined FOXA1 in breast tumor and adjacent normal tissue in relation to reproductive factors, particularly higher parity and no breastfeeding, that are associated with ER− tumors.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 01, 2020
- Source ID
- 10.1158/1055-9965.epi-19-0787
Entities
People
- Angela R. Omilian
- Chi-Chen Hong
- Christine Ambrosone
- Elisa V. Bandera
- Matthew F. Buas
- Michael J. Higgins
- Rochelle Payne-ondracek
- Sirinapa Sribenja
- Song Yao
- Thaer Khoury
- Ting-Yuan David Cheng
- Warren Davis
- Wiam Bshara
Organizations
- Centers for Disease Control and Prevention
- National Cancer Institute
- Roswell Park Comprehensive Cancer Center
- Rutgers University
- United States Army Medical Research and Development Command
- University of Florida