A Genetic Risk Score to Personalize Prostate Cancer Screening, Applied to Population Data
Abstract
A polygenic hazard score (PHS), the weighted sum of 54 SNP genotypes, was previously validated for association with clinically significant prostate cancer and for improved prostate cancer screening accuracy. Here, we assess the potential impact of PHS-informed screening.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 01, 2020
- Source ID
- 10.1158/1055-9965.epi-19-1527
Entities
People
- Adam S. Kibel
- Agnieszka Michael
- Ali Amin Al Olama
- Amanda Spurdle
- Anders M. Dale
- Ben Schöttker
- Bernd Holleczek
- Børge Grønne Nordestgaard
- Cezary Cybulski
- Chavdar Kroumov Slavov
- Christiane Maier
- Chun Chieh Fan
- Csilla Sipeky
- Daniel J. Schaid
- David E. Neal
- David Gillatt
- Dominika Wokolorczyk
- Douglas F. Easton
- Eleanor Walsh
- Emma L Turner
- Freddie C. Hamdy
- Fredrik Wiklund
- Hardev Pandha
- Henrik Grönberg
- Hermann Brenner
- Hui-Yi Lin
- Ian G Mills
- J Kellogg Parsons
- Jenny L Donovan
- Johanna Schleutker
- Jong Y Park
- Judith A. Clements
- Jyotsna Batra
- Kathleen Herkommer
- Kay-tee Khaw
- Kenneth Muir
- Lisa Cannon-Albright
- Manuel Luedeke
- Manuel R. Teixeira
- Markus Aly
- Minh-Phuong Huynh-Le
- Nora Pashayan
- Ole A. Andreassen
- Paul D P Pharoah
- Paula Paulo
- Radka P. Kaneva
- Richard M Martin
- Rosalind Eeles
- Roshan Karunamuni
- Ruth Travis
- Sara Benlloch Garcia
- Shannon K. Mcdonnell
- Sofia Maia
- Stephen N. Thibodeau
- Teuvo L.j. Tammela
- Thomas A. Sellers
- Timothy J. Key
- Tyler M Seibert
- Vanio I. Mitev
- Walther Vogel
- Wojciech Kluzniak
- Zsofia Kote-jarai
Organizations
- Brigham and Women's Hospital
- Cancer Research UK
- Copenhagen University Hospital
- German Cancer Research Center
- H. Lee Moffitt Cancer Center & Research Institute
- Heidelberg University
- Karolinska Institutet
- Karolinska University Hospital
- LSU Health Sciences Center New Orleans
- Mayo Clinic
- NIHR Bristol Biomedical Research Centre
- National Institute for Health and Care Research
- National Institute of Biomedical Imaging and Bioengineering
- Pomeranian Medical University
- Portuguese Oncology Institute
- Queensland University of Technology
- Research Council of Norway
- Sofia Medical University
- Tampere University
- Translational Research Institute
- Turku University Hospital
- United States Department of Defense
- United States Department of Veterans Affairs
- University Hospital Ulm
- University of Bristol
- University of California, San Diego
- University of Cambridge
- University of Copenhagen
- University of Manchester
- University of Oslo
- University of Oxford
- University of Porto
- University of Surrey
- University of Tampere
- University of Turku
- University of Utah School of Medicine
- University of Warwick