Differential Associations of SLCO Transporters with Prostate Cancer Aggressiveness between African Americans and European Americans
Abstract
Androgen receptor signaling is crucial to prostate cancer aggressiveness. Members of the solute carrier family of the organic anion transporting peptides (SLCO) are potential regulators of androgen availability in prostate tissue. It remains unknown whether genetic variations in SLCOs contribute to the differences in prostate cancer aggressiveness in African Americans (AA) and European Americans (EA).
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 22, 2021
- Source ID
- 10.1158/1055-9965.epi-20-1389
Entities
People
- Clayton M. Shanahan
- Elena A. Pop
- Elizabeth T.h. Fontham
- Gary J. Smith
- Gissou Azabdaftari
- James L Mohler
- Jeannette T. Bensen
- Li Tang
- Qianqian Zhu
- Yue Wu
- Zinian Wang
Organizations
- Louisiana State University
- National Cancer Institute
- Roswell Park Comprehensive Cancer Center
- United States Department of Defense
- University of North Carolina at Chapel Hill