Circulating Biomarkers of Inflammation and Ovarian Cancer Risk in the Nurses' Health Studies
Abstract
Chronic inflammation is a well-established mechanism of ovarian carcinogenesis; however, the specific immunogenic processes influencing ovarian tumor development remain unclear. In a case–control study nested within the Nurses' Health Study (NHS) and the NHSII, we examined the association between six inflammatory chemokines and cytokines [B-cell activating factor (BAFF), C-X-C motif chemokine ligand 13 (CXCL13), IL8, soluble(s)IL2-receptor-α(Rα), sIL6Rα] and epithelial ovarian cancer risk.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 09, 2021
- Source ID
- 10.1158/1055-9965.epi-20-1390
Entities
People
- Brenda M Birmann
- Jose R Conejo-Garcia
- Larry I. Magpantay
- Laura Kubzansky
- Lauren C Peres
- Mary K Townsend
- Otoniel Martinez-Maza
- Shelley S. Tworoger
- Yongjoo Kim
Organizations
- H. Lee Moffitt Cancer Center & Research Institute
- Harvard Medical School
- Harvard University
- National Institutes of Health
- United States Department of Defense
- University of California, Los Angeles