The Initial Detection and Partial Characterization of Circulating Tumor Cells in Neuroendocrine Prostate Cancer
Abstract
Purpose: The transition of prostate adenocarcinoma to a predominantly androgen receptor (AR) signaling independent phenotype can occur in the later stages of the disease and is associated with low AR expression +/− the development of small-cell or neuroendocrine tumor characteristics. As metastatic tumor biopsies are not always feasible and are difficult to repeat, we sought to evaluate noninvasive methods to identify patients transitioning toward a neuroendocrine phenotype (NEPC).
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 14, 2016
- Source ID
- 10.1158/1078-0432.ccr-15-0137
Entities
People
- Adam Jendrisak
- David M. Nanus
- Dena Marrinucci
- Himisha Beltran
- Howard I. Scher
- Jessica Louw
- Juan Miguel Mosquera
- Mark Landers
- Myriam Kossai
- Nicole A. Schreiber
- Rachel Krupa
- Ryan Dittamore
- Ryon P. Graf
- Scott T Tagawa
Organizations
- Memorial Sloan Kettering Cancer Center
- United States Department of Defense
- Weill Cornell Medicine