PlGF/VEGFR-1 Signaling Promotes Macrophage Polarization and Accelerated Tumor Progression in Obesity
Abstract
Purpose: Obesity promotes pancreatic and breast cancer progression via mechanisms that are poorly understood. Although obesity is associated with increased systemic levels of placental growth factor (PlGF), the role of PlGF in obesity-induced tumor progression is not known. PlGF and its receptor VEGFR-1 have been shown to modulate tumor angiogenesis and promote tumor-associated macrophage (TAM) recruitment and activity. Here, we hypothesized that increased activity of PlGF/VEGFR-1 signaling mediates obesity-induced tumor progression by augmenting tumor angiogenesis and TAM recruitment/activity.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 14, 2016
- Source ID
- 10.1158/1078-0432.ccr-15-1839
Entities
People
- Ana Batista
- Anna Khachatryan
- Christopher L. Schlett
- Dai Fukumura
- Dan G Duda
- Dan T. Mcmanus
- Ian E. Krop
- Jennifer A. Ligibel
- Joao Incio
- Josh Tam
- Keehoon Jung
- Marek Ancukiewicz
- Masabumi Shibuya
- Nuh N. Rahbari
- Peter Carmeliet
- Priya Suboj
- Rakesh Jain
- Raquel Soares
- Shan M Chin
- Stefan B. Puchner
- Suboj Babykutty
- Tai Hato
- Trupti D. Vardam
- Udo Hoffmman
Organizations
- Fundação para a Ciência e Tecnologia
- Harvard Medical School
- Jobu University
- Katholieke Universiteit Leuven
- Lustgarten Foundation for Pancreatic Cancer Research
- Mar Ivanios College
- Medical University of Vienna
- National Institutes of Health
- St. Xavier's College, Mumbai
- Technische Universität Dresden
- United States Department of Defense
- University Hospital Heidelberg
- University of Porto