The Antitumor Efficacy of IL2/IL21-Cultured Polyfunctional Neu-Specific T Cells Is TNFα/IL17 Dependent
Abstract
Purpose: Infusion of HER2-specific T cells, derived from vaccine-primed patients and expanded with IL2/IL12, has induced tumor regression in a minority of patients with metastatic treatment-refractory HER2+ breast cancer. We questioned whether alteration of cytokine growth factors used to culture vaccine–primed T cells could improve antitumor activity.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 01, 2016
- Source ID
- 10.1158/1078-0432.ccr-15-2273
Entities
People
- Ekram Gad
- Jennifer Childs
- Mary L. Disis
- Vy Phan-lai
- Yushe Dang
Organizations
- National Institutes of Health
- United States Department of Defense
- University of Washington