Voxel Level Radiologic–Pathologic Validation of Restriction Spectrum Imaging Cellularity Index with Gleason Grade in Prostate Cancer
Abstract
Purpose: Restriction spectrum imaging (RSI-MRI), an advanced diffusion imaging technique, can potentially circumvent current limitations in tumor conspicuity, in vivo characterization, and location demonstrated by multiparametric magnetic resonance imaging (MP-MRI) techniques in prostate cancer detection. Prior reports show that the quantitative signal derived from RSI-MRI, the cellularity index, is associated with aggressive prostate cancer as measured by Gleason grade (GG). We evaluated the reliability of RSI-MRI to predict variance with GG at the voxel-level within clinically demarcated prostate cancer regions.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 31, 2016
- Source ID
- 10.1158/1078-0432.ccr-15-2429
Entities
People
- Ahmed Shabaik
- Anders M. Dale
- Christopher J. Kane
- David S. Karow
- Dennis Adams
- Ghiam Yamin
- Hauke Bartsch
- J Kellogg Parsons
- Joshua Kuperman
- Kevin Mccammack
- Natalie M. Schenker-ahmed
- Nathan S. White
- Rebecca A. Rakow-penner
Organizations
- American Cancer Society
- National Science Foundation
- UC San Diego School of Medicine
- United States Department of Defense
- University of California, San Diego