Tumor-Infiltrating Plasma Cells Are Associated with Tertiary Lymphoid Structures, Cytolytic T-Cell Responses, and Superior Prognosis in Ovarian Cancer
Abstract
Purpose: CD8+ tumor-infiltrating lymphocytes (TIL) are key mediators of antitumor immunity and are strongly associated with survival in virtually all solid tumors. However, the prognostic effect of CD8+ TIL is markedly higher in the presence of CD20+ B cells, suggesting that cooperative interactions between these lymphocyte subsets lead to more potent antitumor immunity.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 14, 2016
- Source ID
- 10.1158/1078-0432.ccr-15-2762
Entities
People
- Brad H Nelson
- David R. Kroeger
- Katy Milne
Organizations
- BC Cancer Agency
- Battle Creek Community Foundation
- Canadian Cancer Society Research Institute
- Canadian Institutes of Health Research
- United States Department of Defense
- University of British Columbia
- University of Victoria