Defining a Population of Stem-like Human Prostate Cancer Cells That Can Generate and Propagate Castration-Resistant Prostate Cancer
Abstract
Purpose: We have shown that the phenotypically undifferentiated (PSA−/lo) prostate cancer cell population harbors long-term self-renewing cancer stem cells (CSC) that resist castration, and a subset of the cells within the PSA−/lo population bearing the ALDHhiCD44+α2β1+ phenotype (Triple Marker+/TM+) is capable of robustly initiating xenograft tumors in castrated mice. The goal of the current project is to further characterize the biologic properties of TM+ prostate cancer cell population, particularly in the context of initiating and propagating castration-resistant prostate cancer (CRPC).
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Aug 31, 2016
- Source ID
- 10.1158/1078-0432.ccr-15-2956
Entities
People
- Bigang Liu
- Can Liu
- Collene Jeter
- Dean Tang
- Dingxiao Zhang
- Hsueh-ping Chao
- Jianjun Shen
- Kevin Lin
- Kiera Rycaj
- Qiuhui Li
- Ruifang Liu
- Tammy Calhoun-davis
- Xin Chen
- Xin Liu
- Yue M. Lu
Organizations
- Cancer Prevention and Research Institute of Texas
- Huazhong University of Science and Technology
- National Institutes of Health
- Roswell Park Comprehensive Cancer Center
- Tongji University
- United States Department of Defense
- University of Texas at Austin